Prevalence of hepatitis B virus genotypes among patients with liver disease in Eritrea

Abstract Eritrea is an East African multiethnic country with intermediate endemicity for hepatitis B. Our aim was to establish the most prevalent genotypes of B virus (HBV) among patients liver disease. A total 293 Eritrean disease who were surface antigen (HBsAg) positive enrolled. All sera tested transaminases, HBV DNA viral load, and seromarkers including HBsAg, anti-HBcAb (total), HBeAg, anti-HBeAb. Those reactive HBsAg anti-HBc (total) further genotyping. The median (interquartile range) load ALT levels 3.47 (1.66) log IU/mL 28 (15.3) IU/L, respectively. Using type-specific primer-based genotyping method, 122/293 (41.6%) could be genotyped. Irrespective mode occurrence, genotype D (21.3%) predominant circulating genotype, followed by C (17.2%), E (15.6%), C/D (13.1%), C/E (10.7%). Genotypes C/D/E (7.4%), A/D (4.9%), D/E (4.1%), (2.5%), B, A/E, B/E, A/D/C (0.8%) also present. in comprised a mixture genotypes. This first study Eritrea.